Fatty15 Review (2024): A New Take on Fatty Acid Supplements

Saturated fat has earned a bad rap over the years for its purported roles in heart disease, but we were intrigued to learn that may not always be true during our fatty15 review. While excessive intake may negatively affect heart health, current research is uncovering a whole new perspective on saturated fats. Just ask the dolphins. Yep, you read that right–the dolphins.

Researchers have uncovered an interesting link between dolphins and humans, finding that we are prone to many of the same metabolic conditions. The distinct discovery got scientists digging a little deeper, and they found that some saturated fatty acids may benefit various aspects of health. In fact, they discovered the first essential fatty acid in over 90 years, and fatty15 was born. But does it make the list of best supplements on the market? We think this supplement is a great option for customers seeking a fish oil that doesn’t taste bad, but has all the same benefits of fatty acids normally found in fish oils.

Editor’s note: The content on BarBend is meant to be informative in nature, but it should not be taken as medical advice. The opinions and articles on this site are not intended for use as diagnosis, prevention, and/or treatment of health problems. It’s always a good idea to talk to your doctor before beginning a new fitness, nutritional, and/or supplement routine. Individual needs for vitamins and minerals will vary.

Main Takeaways

• Fatty15 is made with pentadecanoic acid, an essential odd-chain saturated fatty acid.
• Research is limited, but fatty15 provides 100 milligrams of pentadecanoic acid, which is on the low end of what studies have shown effective. 
• The price per serving is higher than your average fatty acid supplement.

Fatty15 Highlights

Fatty15 is the world’s first C15:0 supplement to hit the market. It claims to support your overall wellness by protecting your cellular health from age-related breakdown, and the science-backed research is intriguing. Studies have likened C15:0 to omega-3 fatty acids and their role in regulating the immune system. However, unlike omega-3s, you aren’t smacked in the face with a fishy-smelling supplement when opening a bottle of fatty15.

Fatty15 comes in relatively small capsules, each containing 100 milligrams of the pure, patented form of pentadecanoic acid (FA15). Its founders promote fatty15 as an easy-to-digest supplement that promotes wellness, metabolism, deeper sleep, immune health, heart health, and long-term health benefits. 

Co-founders Dr. Stephanie Venn-Watson and Dr. Eric Venn-Watson of Seraphina Therapeutics relied on their professional experiences to develop fatty15, and they don’t shy away from transparency. Every batch of FA15 used in fatty15 is third-party tested for purity. Plus, fatty15 comes with a 30-day money-back guarantee for first-time buyers. 

[Related: Why Omega-3s Are Extra Helpful for Strength Athletes]

Using Fatty15

Back in 2015, a team of researchers, including one of fatty15’s co-founders, Dr. Stephanie Venn-Watson, made some interesting discoveries when they compared the diets of California and Florida dolphin populations. (1) The dolphins with lower levels of saturated fatty acid C17:0 in their systems were more prone to elevated insulin, triglycerides, glucose, and ferritin–all markers of metabolic syndrome. 

Years later, researchers went on to discover that dolphins who were fed a fish diet rich in pentadecanoic acid or C15:0 experienced improved insulin, cholesterol, and anemia. Higher levels of this essential odd-chain saturated fatty acid were linked to lower risks of chronic metabolic conditions in dolphins on a cellular level. (2) Since humans are also affected by these metabolic conditions, scientists wondered if saturated fatty acids could actually have a place in a well-balanced diet.

Fatty15, made with a patented form of pentadecanoic acid, is a daily fatty acid supplement that is said to promote healthy metabolism, balanced immunity, better sleep quality, heart health, and a clamer mood. While pentadecanoic acid (C15:0) is found in trace amounts in dairy fat and some fish and plant-based sources, fatty15 covers your bases by providing the low end of your recommended daily intake.

Ingredients

Fatty15 contains just one ingredient, a patented form of the saturated fatty acid pentadecanoic acid called FA15. Health initiatives have advised against saturated fats for years. But, as it turns out, not all saturated fats are made the same and pentadecanoic acid may actually offer some health benefits. 

Pentadecanoic acid has been shown to target longevity pathways linked to metabolic conditions like type 2 diabetes, heart disease, cancer, and nonalcoholic liver disease. (3) Since research shows that our bodies don’t produce enough of this fatty acid to support its role in physiological health, we’re seeing a heightened focus on C15:0 supplementation.(5)

To harness the powers of pentadecanoic acid or C15:0, researchers set out to create a vegan-friendly version of the fatty acid typically found in dairy products and some fish. Thus, FA15 was born. FA15 is a pure powder form of pentadecanoic acid manufactured from scratch, and it’s the only ingredient in fatty15. Plus, fatty15 is also lactose- and gluten-free and made without preservatives, fillers, oils, dairy, allergens, or artificial colors. 

Who Needs Fatty15?

While the body can synthesize pentadecanoic acid in small amounts, research suggests that supplementation may benefit certain groups. Thanks to its purported roles in mitochondrial function, pentadecanoic acid, or C15:0, has become a focus for many bodybuilders and other athletes. It’s an odd-chain fatty acid that can be shortened to support mitochondrial energy metabolism, which helps the body deal with times when we need more energy–AKA stressful workouts.(4)

Fatty15 is also marketed towards those who want to support their metabolic health by slowing the age-related breakdown of our cells. Where we once frowned upon saturated fats and their impact on our overall health, we now explore the unique and potentially beneficial mechanisms that pentadecanoic acid offers to healthy aging. Still, while research continues to roll out, it’s important to consult with your doctor before starting this saturated fatty acid supplement. 

Dosing

Fatty15 is formulated as a daily supplement to be taken any time of the day, with or without food. Each capsule provides 100 milligrams of synthetically made pentadecanoic acid in the patented form of FA15. The 100 milligrams per capsule appears to be a conservative dose, as current research shows that 100-300 milligrams daily can maintain effective levels of pentadecanoic acid in the bloodstream. (3)

Cost

Fatty15 is a little more expensive than your average omega-3 fatty acid or fish oil supplement, which might be surprising since it only contains one ingredient. You’re shelling out $1.331-$1.67 per daily dose, depending on your subscription setup. But is its worth a “you get what you pay for” situation? 

Fatty15 is clinically dosed based on current research, and it only contains one ingredient–FA15, the patented form of pentadecanoic acid. However, each batch of the powerful ingredient is third-party tested for purity, meaning you know what’s on the label is exactly what you’re putting into your body. Plus, fatty15 offers several ways to save with bulk buys and subscription deliveries.

Potential Risks

Research surrounding the long-term use of pentadecanoic acid in any form is still evolving, but a recent 2020 study has linked increased levels of the fatty acid with sarcopenia, or skeletal muscle loss. (3) Those at risk for muscle loss, such as older adults, should consult their doctor before starting an FA15 supplement like fatty15. There is also limited data regarding drug-nutrient interactions, so keep that in mind when adding a saturated fatty acid supplement to your day. 

What to Consider Before Buying Fatty15

Our expert testers, including Kate Meier, a member of our editorial team and NASM-certified personal trainer, looked at fatty15 from every angle. They shared insight into their experience using our testing methodology, which considers the following aspects.

Price Per Serving

Fatty15 is available in various kits, ranging from a 30-day supply to a full year’s stock. Depending on your chosen kit, the cost per serving varies between $1.31 and $1.67. Shipping is free on all U.S. orders, and subscriptions can be canceled at any time. 

Glass bottle kit options include:

• 30-Day Trial Kit (with 90-day subscription): $49.95 or $1.67/serving
• 90-Day Starter Kit (with 90-day subscription): $119.95 or $1.33/serving
• 90-Day Starter Kit (without a subscription): $149.95 or $1.67/serving 
• Annual Supply Kit (without a subscription): $459.95 or $1.31/serving

Fatty15 is paving the way for this type of supplement, so it’s tough to compare how its price per serving stacks up against the competition. Still, it’s much more expensive than your standard omega-3 fatty acid supplement.

Formulation

One of our expert testers made a good point when he said, “There isn’t a ton of research on this product yet, but its company claims that it can help replenish and strengthen cells.” With that in mind, we gave fatty15’s formulation a 4 out of 5. We like the product’s simplicity and the fact that it has no fluff formula. You’re paying for clinically dosed C15:0, and that’s precisely what you get–100 milligrams of pentadecanoic acid in its patented form, FA15.

And what little research is available backs the dosing used in fatty15. Scientific studies have shown that consuming between 100 and 300 milligrams of C15:0 can maintain blood levels that promote longevity pathways and positively impact core components of cardiovascular disease, cancer, Type 2 diabetes, and liver disease. (3)

But how can it score so well and only provide the low end of what researchers recommend? Great question! The 100 milligrams per capsule ensures you meet your minimum needs, but it leaves room for other sources of fatty acids in your diet, helping you avoid excessive intake of saturated fats. 

Taste and Swallowability

Fatty acid supplements are usually found in large capsules, but fatty15 is packaged in a small vegetable cellulose capsule that even those sensitive to pills can tolerate. One of our expert testers appreciated the small capsule size, saying, “Since this product is formulated as a daily supplement, I appreciate that it was easy to swallow and didn’t have a taste.”

[Related: Best BCAA Supplements] 

Meier echoed this tester’s thoughts and gave fatty15 a perfect 5 out of 5 for swallowability, saying, “The smaller capsule size was super easy to swallow. I had zero issues!” She also didn’t notice a taste when taking fatty15, earning it another 5 out of 5 for taste. 

Transparency and Third-Party Testing

The FDA is not responsible for regulating dietary supplements, so we love to see supplement companies like fatty15 pursue third-party testing to ensure the safety and purity of their products. Fatty15’s only ingredient, FA15, is manufactured in an FDA-approved facility by their current Good Manufacturing Practices (cGMP). It also undergoes rigorous testing by a third-party lab to ensure ≥ 98% purity of each batch. Because each batch is tested by an unbiased third-party lab, we gave fatty15 a 5 out of 5 score for third party testing.

Side Effects 

Neither of our testers experienced any adverse side effects while trialing fatty15. However, they both emphasized that you would need to consistently take the fatty acid supplement for a very long time to notice any results, good or bad. 

The company’s website states a small percentage of customers report constipation, diarrhea, and headaches while taking fatty15 as recommended. Consider discussing potential side effects with your doctor before starting fatty15. 

Fatty15 vs. The Competition

While fatty15 is the first on the market, we’ve tested hundreds of dietary supplements, including a range of fatty acid products. Comparing fatty15 to omega-3 fatty acids is not a 1:1 comparison, but they’re in the same realm and share the same goals. We pulled a couple of products from our list of best fish oil supplements. Legion Triton Fish Oil sells at a comparable price but offers a significantly different dose of fat. On the other hand, BulkSupplements Fish Oil is way more affordable but provides a smaller amount of DHA and EPA than Legion.

[Related: The Best Fish Oils For Athletes]

	Fatty15	Legion Triton Fish Oil	BulkSupplements Fish Oil
Price per serving	$1.31-$1.67, depending on the chosen kit	$1.49-$1.67, depending on subscription	$0.03-$0.10, depending on amount purchased
Dosing	1 capsule daily	4 capsules daily	1 capsule daily
Dose of fat	100 mg	2,400 mg	300 mg
Type of fat	C15:0	DHA and EPA	DHA and EPA
Third-party tested?	Yes	Yes	Yes

C15:0 and omega-3s are essential fatty acids, meaning our bodies can’t produce them alone. We have to get them from our diet. And while most of us can meet our needs through whole foods alone, supplements are an excellent way to cover any shortcomings in our diet. 

[Related: Best Probiotic Supplements] 

Several factors can influence your decision-making when shopping for the best fatty acid supplements for your needs. Type of fat, amount per serving, third-party testing, and price per serving vary significantly between products. A registered dietitian can help you choose dietary supplements based on your medical history and wellness goals. 

Places to Buy Fatty15

You can purchase fatty15 directly on the company’s website.

Customer Experience

Fatty 15 is available directly on their website, with various kit options to choose. The more you buy, the more you save, especially when you set up a delivery subscription. You can order a one-time purchase of a one-month supply at full price or a whole year’s supply and save $140 overall. Fatty15 allows you to cancel your membership anytime, and shipping is always free for orders.

The customer service information is easy to find on their website, and the FAQ section is very thorough.  

Return Policy

Fatty15 offers a 30-day money-back guarantee for all first-time orders. If you’re not satisfied with the product, you can initiate a return within 30 days of purchase by emailing customer service. You’ll be in contact with a customer service representative who will provide details on how to return the product and when to expect your refund. 

Company Information

Based in San Diego, California, fatty15 is a relatively new company founded after years of research. Founded by Dr. Stephanie Venn-Watson and Dr. Eric Venn-Watson, a husband-and-wife duo, fatty15 combines their background in medicine, veterinary epidemiology, and public health.

Dr. Stephanie Venn-Watson, a veterinary epidemiologist and public health scientist, was involved in many of the clinical trials that explored the health effects of C15:0 on dolphin populations, sparking her curiosity regarding its impact on humans. Her recent TED talks more about the science behind C15:0 and offers insight into the company.

To contact fatty15, you can submit a customer service ticket on the brand’s website, email info@fatty15.com, or call 619-407-9225.

Final Word

Saturated fat has been frowned upon for years and years. But with emerging research indicating a dosed amount may be beneficial to health, we’re seeing a surge in fatty acid supplements on the market. Fatty15 is paving the way for C15:0 supplementation, but continued research is still needed, especially its long-term effects on humans. 

[Related: Best Clean Protein Powders] 

Fatty15 provides 100 milligrams of C15:0 in every capsule, the lowest of what research has shown to be beneficial for daily intake. But isn’t that what supplements are for–to the gap between dietary intake and nutrition needs? The lower dose allows you to consume other sources of pentadecanoic acid without overdoing it. Still, if you have questions about C15:0 and the effects it may have on your health, talk with your doctor or registered dietitian nutritionist. 

Fatty15 FAQs

References

1. Venn-Watson SK, Parry C, Baird M, et al. Increased Dietary Intake of Saturated Fatty Acid Heptadecanoic Acid (C17:0) Associated with Decreasing Ferritin and Alleviated Metabolic Syndrome in Dolphins. PLoS One. 2015;10(7):e0132117. Published 2015 Jul 22. doi:10.1371/journal.pone.0132117
2. Venn-Watson S, Reiner J, Jensen ED. Pentadecanoylcarnitine is a newly discovered endocannabinoid with pleiotropic activities relevant to supporting physical and mental health. Sci Rep. 2022;12(1):13717. Published 2022 Aug 23. doi:10.1038/s41598-022-18266-w
3. Venn-Watson S, Schork NJ. Pentadecanoic Acid (C15:0), an Essential Fatty Acid, Shares Clinically Relevant Cell-Based Activities with Leading Longevity-Enhancing Compounds. Nutrients. 2023; 15(21):4607. https://doi.org/10.3390/nu15214607
4. Pfeuffer M, Jaudszus A. Pentadecanoic and Heptadecanoic Acids: Multifaceted Odd-Chain Fatty Acids. Adv Nutr. 2016;7(4):730-734. Published 2016 Jul 15. doi:10.3945/an.115.011387
5. Venn-Watson S, Lumpkin R, Dennis EA. Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential? Sci Rep. 2020;10(1):8161.